Aquino appeared on Broadway in Wasserstein's The Heidi Chronicles. Her off-Broadway credits include Cold Sweat, Right Behind the Flag and Love Diatribe. She is a familiar face from her work on the big and small screens. She starred in the television series Brooklyn Bridge and Madman of the People and has had recurring roles on ER, Felicity, Picket Fences, Judging Amy and Crossing Jordan. Her film credits include Moonstruck, Working Girl, Boys on the Side, White Oleander, National Security, The Signing Detective, Woman Thou Art Loosed and A Lot Like Love.