Best will play Josie, the woman with a ruined reputation who lives in a dilapidated Connecticut farmhouse with her father and falls in love with Spacey's Jim Tyrone-a third-rate actor whose dreams of stardom were washed away by alcohol.
The production will be directed by Howard Davies, who has worked with both stars before on separate O'Neill plays. Spacey previously starred in Davies' production of The Iceman Cometh that originated at Islington's Almeida Theatre before transferring to the Old Vic and Broadway. Best starred in Mourning Becomes Electra, directed by Davies, at the National's Lyttelton in a production that won her the Critics' Circle Award for Best Actress. Last year she won the same award again, plus the Olivier and Evening Standard Awards, for her performance in the title role of the Almeida production of Hedda Gabler that subsequently transferred to the West End's Duke of York's. Her other credits include Tom Stoppard's The Coast of Utopia trilogy and The Cherry Orchard at the National, as well as Katie Mitchell's National Theatre production of Three Sisters. For her role in 'Tis Pity She's A Whore at the Young Vic, she earned the Evening Standard and Critics' Circle Newcomer Award.
A Moon for the Misbegotten runs at the Old Vic through December 23.