As a New York stage actress, Manheim appeared in several off-Broadway productions in the late 80s and early 90s including Stella, Woyzeck at the Public, The Triumph of Love, Sin and Missing Persons at the Atlantic Theater, for which she won an Obie Award and was nominated for a Drama Desk Award. She also appeared as Lucetta in the 1994 Shakespeare in the Park production of Two Gentlemen of Verona. Manheim received great attention and acclaim for her 1995 solo show at the Public Theater called Wake Up, I'm Fat, which was later adapted into a book. Although she has never appeared on Broadway, Manheim considered playing Jessie in the 2004 revival of 'night, Mother, a role that eventually went to Edie Falco.
Directed by Michael Greif Grey Gardens, Rent, Romeo & Juliet will run from June 5 to July 8 at the Delacorte Theater in Central Park. As previously announced, Oscar Isaac and Lauren Ambrose will play the title roles.