Mizrahi is known for his eponymous fashion lines and being a judge on Project Runway All Stars. He is a Drama Desk Award winner for his costume designs in 2002's The Women. He also designed costumes on Broadway for revivals of Barefoot in the Park and The Threepenny Opera. He has an annual residency at Café Carlyle in New York City and has performed at various venues across the country such as Joe’s Pub, the Regency Ballroom and several City Winery locations nationwide. Mizrahi has directed productions of A Little Night Music and The Magic Flute for the Opera Theatre of St. Louis. He annually directs and narrates a production of the children’s classic Peter and The Wolf at the Guggenheim Museum in New York. Chicago marks his Broadway acting debut.